Current Research Projects
Host-Microbiome Interaction: Implications for cellular and global energy metabolism of dairy cows (WiMiQ)
WiMiQ
2024- 2026
In collaboration with FLI Braunschweig (Dr J. Frahm, Prof. S. Dänicke), Uni Bonn (Prof. H. Sauerwein)
Publications
from previous project MitoCow
Tröscher-Mußotter J, Saenz JS, Grindler S, Meyer J, Kononov SU, Mezger B, Borda-Molina D, Frahm J, Dänicke S, Camarinha-Silva A, Huber K, Seifert J (2021) Microbiome clusters disclose physiologic variances in dairy cows challenged by calving and lipopolysaccharides.
mSystems 6(5):e00856; doi.org/10.1128/mSystems.00856-21
Tröscher-Mußotter J, Deusch S, Borda-Molina D, Frahm J, Dänicke S, Camarinha-Silva A, Huber K, Seifert J (2022) Cow’s microbiome from antepartum to postpartum: A long-term study covering two physiological challenges.
Frontiers in Microbiology 13. doi: 10.3389/fmicb.2022.1000750
Project in the DFG Research Unit ‘Appearance and physiological relevance of inositol phosphates and myo-inositol in the domesticated fowl’ FOR 2601
Project time: 2022-2025
People
Groups
- Functional Microbiology of Livestock
- Microbial Ecology of Livestock
- Institute of Animal Science
2023-2026
Funding: Bundesanstalt für Landwirtschaft und Ernährung
Groups
This is a collaborative project with Prof. Amélia Camarinha-Silva und Prof. Markus Rodehutscord.
Partnership program The Hebrew University of Jerusalem – University of Hohenheim
2024-2025
Dr. Kfir Sharabi (Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem)
Duration: 2017-2022
DFG (SE 2059/3-1)
People
- Dr. Andrej Trautmann
- Prof. Dr. Julia Fritz-Steuber
- Prof. Dr. Jana Seifert
Publications
Deusch S, Bok E, Schleicher L, Seifert J, Steuber J (2019) Occurrence and function of the Na+-translocating NADH:Quinone oxidoreductase in Prevotella spp. Microorganisms 7(5), 117, doi: 10.3390/microorganisms7050117
Schleicher L, Fritz G, Seifert J, Steuber J (2020) Anoxic cell rupture of Prevotella bryantii by high-pressure homogenization protects the Na+-translocating NADH:quinone oxidoreductase from oxidative damage. Archive of Microbiology 202, 1263–1266, doi: 10.1007/s00203-019-01805-x
Trautmann A, Schleicher L, Deusch S, Gätgens J, Steuber J, Seifert J (2020) Short-chain fatty acids modulate metabolic pathways and membrane lipids in Prevotella bryantii B14. Proteomes. 8, 28; doi:10.3390/proteomes8040028
Schleicher L, Trautmann A, Stegmann D, Fritz G, Gätgens J, Bott M, Hein S, Simon J, Seifert J, Steuber J (2021) A sodium-translocating module linking succinate production to formation of a membrane potential in Prevotella bryantii. Applied and Environmental Microbiology. doi.10.1128/AEM.01211-21.
Trautmann A, Schleicher L, Pfirrmann J, Boldt C, Steuber J, Seifert J (2021) Na+-coupled respiration and reshaping of extracellular polysaccharide layer counteract monensin-induced cation permeability in Prevotella bryantii B14. International Journal of Molecular Sciences 22: 10202; doi.10.3390/ijms221910202.
Trautmann A, Schleicher L, Koch A, Günther J, Steuber J, Seifert J. (2022) A shift towards succinate-producing Prevotella in the ruminal microbiome challenged with monensin. Proteomics. e2200121. doi: 10.1002/pmic.202200121
Hau JL, Schleicher L, Herdan S, Simon J, Seifert J, Fritz G, Steuber J (2023) Functionality of the Na+-translocating NADH:quinone oxidoreductase and quinol:fumarate reductase from Prevotella bryantii inferred from homology modeling. Archives in Microbiology. 206(1):32. doi: 10.1007/s00203-023-03769-5.
Start: 01.08.2019
Wilhelm Schaumann Stiftung
People
- M.Sc. Alina Kurz
- Prof. Jana Seifert
Collaborators
This is a collaborative project together with Prof. Amélia Camarinha-Silva, Prof. Markus Rodehutscord and Prof. Jörn Bennewitz.
Publications
Kurz A, Seifert J (2021) Factors Influencing Proteolysis and Protein Utilization in the Intestine of Pigs: A Review.
Animals 11(12):3551; doi.org/10.3390/ani11123551
Sarpong N, Seifert J, Bennewitz J, Rodehutscord M, Camarinha-Silva A (2024) Microbial signatures and enterotype clusters in fattening pigs: implications for nitrogen utilization efficiency.
Frontiers in Microbiology.15. doi: 10.3389/fmicb.2024.1354537
Schmid M, Weishaar R, Seifert J, Camarinha-Silva A, Rodehutscord M, Bennewitz J (2024) Genomic analyses of nitrogen utilization efficiency, its indicator trait blood urea nitrogen and the relationship to classical growth performance and feed efficiency traits in a Landrace x Piétrain crossbred population.
Journal of Animal Breeding and Genetics. doi: 10.1111/jbg.12864
Terminated Research Projects
01.07.2017 - 2022
People
- M.Sc. Johanna Tröscher-Mußotter
- Prof. Dr. Korinna Huber
- Prof. Dr. Jana Seifert
- Prof. Dr. rer. nat. Amélia Camarinha Silva
Groups
- Fg. Funktionelle Mikrobiologie be Nutztieren
- Fg. Funktionelle Anatomie der Nutztiere
- Fg. Mikrobielle Ökologie bei Nutztieren
- Hohenheim Center for Livestock Microbiome Research (HoLMiR)
- Institut für Nutztierwissenschaften
Publications
Tröscher-Mußotter J, Saenz JS, Grindler S, Meyer J, Kononov SU, Mezger B, Borda-Molina D, Frahm J, Dänicke S, Camarinha-Silva A, Huber K, Seifert J (2021) Microbiome clusters disclose physiologic variances in dairy cows challenged by calving and lipopolysaccharides.
mSystems 6(5):e00856; doi.org/10.1128/mSystems.00856-21
Tröscher-Mußotter J, Deusch S, Borda-Molina D, Frahm J, Dänicke S, Camarinha-Silva A, Huber K, Seifert J (2022) Cow’s microbiome from antepartum to postpartum: A long-term study covering two physiological challenges.
Frontiers in Microbiology 13. doi: 10.3389/fmicb.2022.1000750
Project within DFG Research Unit ‘Appearance and physiological relevance of inositol phosphates and myo-inositol in the domesticated fowl’ FOR 2601
Projektbeginn: 01.05.2018
Projektende: 31.12.2021
People
Publications
Röhm K, Gonzalez-Uarquin F, Harmel RK, Trung MN, Diener M, Fiedler D, Huber K, Seifert J. (2021) Investigation of a potential electrogenic transport-system for myo-inositol in the small intestine of laying hens. British Poultry Science; doi.org/10.1080/00071668.2021.1958301
Röhm K, Diener M, Huber K, Seifert J. (2021) Characterization of the cecal smooth muscle contraction in laying hens. Veterinary Sciences 8(6), 91; doi.org/10.3390/vetsci8060091
Project in the DFG Research Unit ‘Appearance and physiological relevance of inositol phosphates and myo-inositol in the domesticated fowl’ FOR 2601
Project time: 2018-2022
People
Groups
- Functional Microbiology of Livestock
- Microbial Ecology of Livestock
- Institute of Animal Sciences
Publications
Roth C, Sims T, Rodehutscord M, Seifert J, Camarinha-Silva A. (2022) The active core microbiota of two high-yielding laying hen breeds fed with different levels of calcium and phosphorus.
Frontiers in Physiology 13. doi:10.3389/fphys.2022.951350.
Project time: 2019-2022
Funding: EU, BMBF
Researchers
Groups
- Fg. Funktionelle Mikrobiologie bei Nutztieren
- Institut für Nutztierwissenschaften
Publications
Serrano-Villar S, Tincati C, Raju SC, Sáenz JS, Moreno E, Bargiela R, Cabello A, Sendagorta E, Kurz A, Perez Molina JA, de Benito A, Hov JR, Fernandez-Lopez L, Muriel A, del Campo R, Moreno S, Trøseid M, Seifert J, Ferrer M. (2023) Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer.
Nature Medicine. 29. 1738-1749. doi:10.1038/s41591-023-02407-3
Baden-Württemberg, MWFK, Junior-Professuren Programm, 2014 – 2017