Forschungsprojekte
Metabolic labeling of complex microbial communities (MSCA-DN METAMIC3)
Laufzeit: seit 01.10.2025
Förderkennzeichen: HORIZON TMA MSCA Doctoral Networks
METAMIC3 - Metaproteome-based leveraged microbiome management in the context of One Health
Beteiligte Personen
- Prof. Dr. Jana Seifert
- M.Sc. Ashraful Abid

This project aims to applying protein-labeling techniques such as protein-stable isotope probing (SIP) and click chemistry approaches such as bioorthogonal non-canonical amino acid tagging (BONCAT) for an enhanced identification of metabolic active microbes (WP3). We will apply these techniques to reconstruct metabolic networks in microbial communities originating from various environmental and organismal samples, identify the cellular response of single species, or simplify MOCK communities relevant to specific objectives described in WP1. This will reveal the influence of antimicrobial effectors in different microbiomes. In addition, the replication of phages triggered by microbe-phage interactions or environmental stress will be confirmed by BONCAT (in collaboration with AUAS).

